It isn’t clear what all the skill books actually do, so you’ll need to do some experimentation on your own.
Some of the skill book combos are completely, insanely broken. It’ll all become clear in the list below. That means you can’t combine two elemental skill books together.
To use Skill Book combo abilities, you’ll need at least one level in both types of magic - combos only seem to work when combining elemental magic and non-elemental magic. There’s a ton of awesome abilities out there, so instead of going in blind, here’s a full list of Level 1 Skill Book combos. In-game, there’s no way to know what you’ll get before combining two skills books. Divinity: Original Sin 2 adds plenty of interesting wrinkles to the western-RPG formula, and one of those wrinkles is the ability to combine two skill books and create an entirely new ability.