Click “Yes” again, and then restart your PC. If the drive is currently in use, you’re warned that you must restart your PC to finish the process. For example, if you installed an application on this drive or stored important files on it, you won’t be able to access them while the drive doesn’t have a letter assigned to it. Windows warns you that programs may not run correctly if you remove the drive letter. If the partition has multiple drive letters assigned to it, you’ll probably want to remove each from here. Select the drive letter you want to remove in the window that appears, click the “Remove” button, and then click the “OK” button.Įach partition generally has only a single drive letter. You’ll need to use the diskpart command to remove the drive letter. If you don’t see any options other than “Help “when you right-click a drive, continue to the next section instead. Right-click that partition, and then select the “Change Drive Letter and Paths” command.